Sinergy Seminar – Kim Jin Soo, Genome Editing Beyond CRISPR

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SINERGY

Supported by Synthetic Biology for Clinical & Technological Innovation (SynCTI) and Society for Synthetic Biology (Singapore)

Centre for Life Sciences (Auditorium)

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Date: Tuesday, 25 July 2023, 3.30pm (Singapore Time)Venue: Centre for Life Sciences (Auditorium), 28 Medical Drive, #01-07, Singapore, 117456Speaker: Professor Kim Jin SooTitle: Genome Editing Beyond CRISPRAbstract:Genome editing in nuclear, mitochondrial, and chloroplast DNA is broadly useful for biomedical research, medicine, and biotechnology. CRISPR systems, widely used for nuclear DNA editing, are not suitable for organellar DNA editing, due to the difficulty of guide RNA delivery into organelles. Mitochondrial DNA editing paves the way for disease modeling of mitochondrial genetic disorders in cell lines and animals and can offer treatment options for these diseases with unmet medical needs. Likewise, chloroplast DNA editing in plants provides unique opportunities in plant biotechnology and agriculture, contributing to carbon neutralization. I will present novel tools for A-to-G and C-to-T base editing of organellar DNA in human cells, animals, and plants.

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