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in vivo Imaging Seminar

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Conference Room 1114, Department of Pharmacology

Srisawarindhira Building, 11th Floor

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok

Thailand

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ABSTRACT:
Monitoring Disease States in Live Animals Using Non-invasive Optical Imaging

Kevin P. Francis Ph.D, Fellow at PerkinElmer and Visiting Professor at UCLA
and Texas A&M


PerkinElmer is a global leader in the development of instrumentation and probes for small animal non-invasive imaging, including optical, PET and μCT imaging. Through optical imaging, we have developed a technology which allows biological processes, including gene expression that is temporally and spatially defined, to be non-invasively monitored both longitudinally and in real-time. Genes encoding optical reporters, luciferases and fluorescent proteins, are engineered into cells (cancer cells, stem cells etc) and pathogens (bacteria, fungi, protozoa and viruses), or directly into animals (e.g., for monitoring host responses) to enable the generation of light that can be visualized through the tissues of a live animal. PerkinElmer is the only company to have optimized this technique to allow true three-dimensional optical imaging and tomographic multimodality imaging (e.g., through co-registration of optical imaging with μCT and MRI). Furthermore, this technique is equally applicable to imaging of fluorescent dyes and particles, allowing fluorescently tagged biological events (e.g., tracking of antibodies, peptides, and viral capsids) to be monitored both independently and in combination with genetically tagged events. An overview of in vivo optical imaging will be presented, with an in-depth focus on oncology models.


SPEAKER:
Dr Kevin Francis

Dr Kevin Francis joined Xenogen Corporation, now part of PerkinElmer, in January 1999 as Director of Infectious Disease Research, before becoming Head of Biology R&D. He is currently a Fellow within this organization, helping to direct scientific innovation both internally and externally through collaborative research with PE’s extensive customer base. In February 2008 Kevin was awarded an Honorary Professorship in the Department of Surgery at the University Medical Center Groningen, and currently serves as a Visiting Professor in the Department of Orthopaedic Surgery at UCLA and in the Department of Microbial Pathogenesis and Immunology at Texas A&M. Kevin received his Ph.D in Molecular Biology from the University of Edinburgh in 1994, and has been involved in the development of novel bioluminescent reporter systems and preclinical models of disease for the past 25 years.


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Conference Room 1114, Department of Pharmacology

Srisawarindhira Building, 11th Floor

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok

Thailand

View Map

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