FCS Satellite Symposium - Understand Nature's Complexity

Miltenyi Biotec Asia Pacific Pte. Ltd.

We invite you to our Satellite Symposium at the FCS Symposium where the experts share the latest microscopy and spatial biology technologies

Flexi Space at Level 20 (LKCMed, Novena Campus

<h3>Understand Nature's Complexity </h3>Date: November 7, 2022Time: 12:30 p.m. - 1:30 p.m. (Singapore Standard Time)<h3>A﻿genda:</h3><h3></h3>12:30 p.m. - 1:00 p.m. The MACSima™ Imaging Platform – The only complete solution for ultrahigh content imaging, tapping the full potential of spatial biologyDr. Telma Santos, Miltenyi Biotec, GermanyA﻿bstract: The MACSima Imaging Platform is the only complete solution for ultrahigh-content imaging experiments. At its core is the MACSima Imaging System, a fully automated instrument based on fluorescence microscopy. Together with a broad spectrum of recombinant pre-validated, ready-to-use antibodies and specifically designed sample carriers it allows the analysis of hundreds of markers on a single sample, multiple samples at a time. The powerful and intuitive MACS® iQ View Analysis Software makes for a truly game-changing imaging experience enabling you to push the boundaries of spatial biology.1:00 p.m. - 1:30p.m.Visualizing cancer - From functional phenotyping to precision immunotherapyDr. Christian Seitz and Sophia Scheuermann, University Children’s Hospital Tübingen, GermanyA﻿bstract: What are the underlaying mechanisms that lead to the limited effects of immune therapies, in specific, chimeric antigen receptor (CAR) technologies, in solid tumors and how can we identify new therapeutic approaches to overcome those hurdles? By using the MACSima platform, we try to answer these questions for different solid cancers such as pediatric sarcomas and neuroblastomas, as well as for major adult cancer subtypes like lung and liver cancer.We started our experiments doing feasibility studies with reference tissue, different tumor entities and defined comprehensive antibody panels with more than 100 markers. This enabled us to identify a variety of stromal components, immune cells, heterogeneous tumor tissue, and clinically relevant and druggable target antigens, like immune checkpoints. On the one hand, we implemented the ultra-high content imaging workflow into our pre-clinical research to study the interaction between CAR-T cells, the tumor, and its tumor microenvironment (TME) i.e. in cell culture experiments and in vivo studies, whereas the goal is the characterization of CAR-T cells in a reproducible and coherent way. On the other hand, the MACSimaTM is used as an “on-the-fly” diagnostics tool in Tübingen, which complements classical pathology, offers a deeper and previously impossible understanding of tumor samples, and has the potential to improve precision immunotherapy.<h3>Speakers Information</h3><ul><li>Telma Santos gained ten years of experience in fluorescence microscopy in academia and industry and combines expert knowledge in a wide range of microscopy techniques such as confocal microscopy, STED, and spinning disc microscopy for live-cell and 3D imaging. After studying axonal growth at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, Germany, Telma joined Miltenyi Biotec in 2019 and is currently part of the team managing the market access of the MACSima™ Imaging Platform.</li><li>Christian Seitz, M.D., is a pediatrician at the University Children’s Hospital Tübingen, Germany. He studied medicine at the universities in Ulm and Frankfurt, Germany, as well as at the National Cancer Institute in Bethesda, MD, USA. He received his doctorate, Dr. med., from the Goethe University Frankfurt, Germany. In 2014, he started his clinical training in pediatrics under Rupert Handgretinger at the University Children’s Hospital Tübingen, focusing on stem cell transplantation and cellular therapies. His scientific work is focused on the development and clinical translation of modular chimeric antigen receptor (CAR) technologies and </li><li>Sophia Scheuermann, M.Sc. in Biochemistry, is a PhD candidate in the Advanced Cellular Therapies (ACT) Lab of Dr. Christian Seitz at the University Children's Hospital Tübingen, Germany. She studied life sciences and biochemistry at the Universities of Konstanz and Tübingen. She extended her knowledge about protein biochemistry, mass spectrometry, and immunology as a visiting researcher at the University of British Columbia, Vancouver, Canada. She finished her studies in 2020 in the lab of Dr. Christian Seitz with her master's thesis about "Strategies to improve the performance of CAR-T cells by targeted integration". In her current scientific work, she is focusing on the improvement of cellular and immune therapies for solid tumor settings. In specific, she is interested in the investigations of the interplay between chimeric antigen receptor (CAR) therapy and the tumor microenvironment (TME).</li></ul>

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FCS Satellite Symposium - Understand Nature's Complexity

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